The Carthaginian scourge of Sicily, which began 409, made Acragas (Agrigentum), on the southwest coast, the target three years later. Employing the same tactics he used successfully at Selinus and Himera, Hannibal (not to be confused with the famed general at the Punic Wars) laid siege on the city, which was commanded by Dexippus, a spartan. Although an epidemic swept through Carthaginian camp, killing Hannibal and many others, Himilco, a cousin, succeeded to the command and continue the siege.
As in the earlier battles, a force of Syracusans, this time 35,000 men commanded by Daphnaeus, marched to the relief of the city. Under the walls of Acragas a pitched battle took place, in which the Carthaginians were partially defeated. However, dissension broke out among Sicilians, and many mercenaries deserted. Finally, after eight months, the entire garrisons abandoned the city, which was then occupied by victorious Himilco.